منابع مشابه
Synthetic morphogenesis: space, time, and deformation
Synthetic biology has presented engineers with a fascinating opportunity: can we understand the principles of our origins – animal embryonic development – by reengineering it in the laboratory? I investigate, from an engineer’s perspective, some of problems that arise in developing geometric form in a deformable substrate. More abstractly, I attack the problem of establishing spatial patterns, ...
متن کاملNeural tube morphogenesis in synthetic 3D microenvironments.
Three-dimensional organoid constructs serve as increasingly widespread in vitro models for development and disease modeling. Current approaches to recreate morphogenetic processes in vitro rely on poorly controllable and ill-defined matrices, thereby largely overlooking the contribution of biochemical and biophysical extracellular matrix (ECM) factors in promoting multicellular growth and reorg...
متن کاملBeyond Morphogenesis Enhancing synthetic trees through death, decay and the Weasel Test
Artificial Life and Computer Graphics merge prominently in the production of virtual trees. This paper highlights several issues seldom raised by procedurally generated, synthetic landscape imagery that result in a perceived lack of authenticity or drama. Some of the concerns discussed include a need for models of decay and an understanding of the tree’s role in the environment and within human...
متن کاملSynthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis
Epithelial cells cultured within collagen and laminin gels proliferate to form hollow and polarized spherical structures, recapitulating the formation of a rudimentary epithelial organ. However, the contributions of extracellular matrix (ECM) biochemical and biophysical properties to morphogenesis are poorly understood because of uncontrolled presentation of multiple adhesive ligands, limited c...
متن کاملIdentifying ultrasensitive HGF dose-response functions in a 3D mammalian system for synthetic morphogenesis
Nonlinear responses to signals are widespread natural phenomena that affect various cellular processes. Nonlinearity can be a desirable characteristic for engineering living organisms because it can lead to more switch-like responses, similar to those underlying the wiring in electronics. Steeper functions are described as ultrasensitive, and can be applied in synthetic biology by using various...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2016
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a023929